Ankylosing Spondylitis

A chronic progressive inflammatory disorder that, unlike other rheumatological diseases, affects men more often than women. It involves primarily the joints between articular processes, costovertebral joints, and sacroiliac joints, and occasionally, the iris or the heart valves. Bilateral sclerosis of sacroiliac joints is a diagnostic sign. Affected persons have a high incidence of a specific human leukocyte antigen (HLA-B27), which may predispose them to the disease. Changes occurring in joints are similar to those seen in rheumatoid arthritis. Ankylosis may occur, giving rise to a stiff back (poker spine). Nonsteroidal anti-inflammatory drugs (NSAIDs) and physical therapy are the primary forms of treatment.

Synonyms: Ankylosing spondylitis is also known by the names rheumatoid spondylitis and Marie-Strumpell spondylitis.