Ankylosing spondylitis

Ankylosing spondylitis is a chronic progressive inflammatory disorder that, unlike other rheumatological diseases, affects men or more often than women. It involves primarily the joints between articular processes, costovertebral joints, and sacroiliac joints, and occasionally, the iris or heart valves. Bilateral sclerosis of sacroiliac joints is a diagnostic sign. Affected persons have a high incidence of a specific human leukocyte antigen (HLA-B27), which may predispose them to the disease. Changes occurring in the joints are similar to those seen in RA. Ankylosis may occur, giving rise to a stiff back (poker spine). NSAIDs (Non steroidal Anti-inflammatory Drugs) and physical therapy are the primary forms of treatment.